Almost certainly everyone will be a loser from Brexit, but many of the groups that voted for it will be especially disadvantaged. That is truly a tragedy.
Politicians bear a heavy burden for the blame for this.
The same regions are however blighted by significantly long-term government inattention and low investment, resulting in low wages, low levels of education and high unemployment..
It is the responsibility of government to address such problems and not take a further set of disastrous decisions to distract attention away from their previous failures.
The Brexit vote is about failed policies on housing and developing deprived regions and not based on any credible economic argument.
The biggest irony is that these regions will suffer greatly from what the political class is about to do.
For four decades the Tory party has stalled the UK on the Europe question.
This is four decades during which the UK could have quite easily led Europe into a strong democratic free market model.
That didn't happen because of petty Tory in-fighting.
And now we seem to be trusting second rate poltiticians with no experience of a real job to navigate us out of our major export market and years of prosperity with the slogan 'the EU needs us more than we need them.'
In fact the EU won't need us very much because the EU is a trading bloc of 27 countries who can take the 'hit' very easily. We are one country and we almost certainly do need the EU for jobs and growth.
If we leave the EU then people in the UK will be poorer as a result and in 20 years time our children will be asking why France and Germany have twice the living standard of our country.
That is where we are right now.
Possibly the most disappointing thing is a lack of any leadership quality: a referendum that squeeked through on ridiculous promises and minimal arguments warranted, more than anything else, leadership: many people voting thought the vote didn't matter because it wasn't a general election.
Instead of that, a somewhat weak Prime Minister has chosen to take a 'hard line' and a 'hard Brexit' in order to appease the right wing of her own party. This lady was for remaining in the EU in the past.
Perhaps the Prime Ministers most neglectful mistake though was to fire the Article 50 'gun' (again, in order to appease the right of her party) before formulating any plans of what Brexit was wanted. If one were to look for an example of how this Government is ruling to prop up its own unity and survival, but at the expense of the country's future: this is a prime example.
"The day after we vote to leave, we will hold all the cards." Michael Gove
"We will be free to neogiate our own trade deals" All brexiteers said this at the time of the referendum. (most have retrenched from this statement subsequently)
On the promise to spend £350m a week on the NHS after EU withdrawal:-
"I never made that promise, I think 'they' made a mistake saying that." Nigel Farage
"It is not a promise broken, I never said that during the course of the election" Ian Duncan Smith
On immigration numbers:-
"The leave campaign never promised to cut immigration numbers and the free movement of workers to and from the UK should continue to ensure Britain remains within the single market"Tory Eurosceptic MEP Daniel Hannan on BBC Newsnight